![]() ![]() Not using Dropbox Passwords yet? See how Dropbox helps you store and sync passwords. The account’s username, password, password strength, website URL, and the date the account was added to Dropbox Passwords will appear. Dropbox passwords aprilcarlos campbell theverge free Passwords secures your credentials with zero-knowledge encryption, so your passwords are only accessible to you and not Dropbox. To view specific account details, click the account name. Encuentra guas acerca de cmo guardar las credenciales de inicio de sesin de tus cuentas y tus tarjetas de pago, cmo monitorear la seguridad de tu cuenta, y ms. You can also sort accounts by A-Z, Z-A, or Password strength. Obtn ayuda y soporte al usar Dropbox Passwords. LastPass and 1Password each cost 36 per year, and Keeper undercuts those by a buck ( eight dollars (opens in new tab) if youre a Toms Guide reader). We know that working and keeping in touch is a little different at the moment, so we are excited to announce some amazing new features for Dropbox Plus users to help you stay organized and get more done, without adding any more stress. Under the Password alerts tab, you can filter accounts by Weak, Reused, or All passwords. Family Plan, Dropbox Passwords, Plus a lot more. Access passwords anywhere with automatic syncing on up to three devices. With Passwords in Dropbox Basic, you can: Store your 50 most important passwords in one secure place. If you want to be notified when an account has been breached, enable breach monitoring. Now, with a free Dropbox Basic plan, you can try a limited version of Passwords. Under the Breaches tab, you can see if an account linked to an email address you’ve stored in Passwords has been compromised. From the dashboard, you can view Breaches and Password alerts. Dropbox Family: Creating a digital hub for your loved ones. Computer backup is now available on Dropbox Basic, Plus, and Professional plans. ![]() In the dropdown, click Security dashboard. Introducing Dropbox Passwords: Store and sync passwords across all devices.Click your initials in the top right corner. Dropbox Passwords, the password management feature the company introduced for paying customers in 2020, will be free for Dropbox Basic accounts in April with a new, arbitrary limit of.Open the Dropbox Passwords browser extension.The security dashboard can only be accessed from the Dropbox Passwords browser extension. You can view and access data about your accounts in the Dropbox Passwords security dashboard, which shows if any of your accounts have been breached or have weak or reused passwords. ![]()
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1/7/2024 0 Comments Er lumen oxidizing![]() ![]() What is known is that in vitro refolding of proteins of the insulin/IGF superfamily proceeds stepwise via one- and two-disulfide intermediates, in which a molten globule containing the B19-A20 disulfide bond is critical ( 17– 19). Nevertheless, few studies have actually examined the pathway(s) of proinsulin folding and misfolding within the β-cell ER. It is recognized that all three disulfide bonds of insulin, the two “interchain” disulfide bonds called Cys(B7)-Cys(A7) and Cys(B19)-Cys(A20) as well as the intra-A chain disulfide Cys(A6)-Cys(A11)-all of which form within proinsulin-must be intact for optimal insulin bioactivity on the insulin receptor ( 16). The process of proinsulin disulfide bond formation in vivo is complicated by the rapid time scale (<1 min) for proinsulin translation/translocation into the ER lumen ( 11), the timing of preproinsulin signal peptide cleavage ( 12), the regulation of the ER lumenal redox environment ( 13, 14), and activity of ER oxidoreductases ( 15). ![]() To the best of our knowledge, all MIDY mutations perturb the native disulfide pairing of proinsulin ( 9, 10). The clearest model of β-cell failure triggered by proinsulin misfolding currently comes from a cluster of autosomal dominant INS gene mutations that produce the syndrome we call MIDY (mutant INS gene–induced diabetes of youth) ( 8). These data suggest possible therapeutic avenues to ameliorate ER stress and diabetes. MIDY mutations inhibit Cys(B19)-Cys(A20) formation, but treatment to force oxidation of this disulfide bond improves folding and results in a small but detectable increase of proinsulin export. The three most common proinsulin disulfide mispairings in the ER appear to involve Cys(A11)-Cys(A20), Cys(A7)-Cys(A20), and Cys(B19)-Cys(A11), each disrupting the critical Cys(B19)-Cys(A20) pairing. Interestingly, formation of these two “interchain” disulfide bonds demonstrates cooperativity, and together, they are sufficient to confer intracellular transport competence to proinsulin. In the absence of preexisting proinsulin disulfide pairing, Cys(B19)-Cys(A20) (a major determinant of ER stress response activation and proinsulin stability) preferentially initiates B-A chain disulfide bond formation, whereas Cys(B7)-Cys(A7) can initiate only under oxidizing conditions beyond that existing within the ER of β-cells. Herein, we have undertaken a molecular dissection of proinsulin disulfide bond formation, using bioengineered proinsulins that can form only two (or even only one) of the native proinsulin disulfide bonds. Proinsulin folding within the endoplasmic reticulum (ER) remains incompletely understood, but it is clear that in mutant INS gene–induced diabetes of youth (MIDY), progression of the (three) native disulfide bonds of proinsulin becomes derailed, causing insulin deficiency, β-cell ER stress, and onset of diabetes. ![]() 1/7/2024 0 Comments Uses for kindle for kids![]() Some might question the decision of Amazon to place a store selection prominently on the second hub screen, tantalizingly showing off heavyweight titles like The Books of Earthsea and The Hunger Games. I noticed a couple of comics on there too, and the Kindle’s compact monochrome E-Ink display is not well suited to such an image-led format. It’s a decent selection, but far from comprehensive, as we pointed out in our Kindle Kids (2019) review. If you’re a one Kindle kind of a family, this could be all the e-reader you’ll ever need.Īs part of the package, you also get a free one-year subscription to Amazon Kids+, which gives you free access to more than 1,000 child-friendly e-books. Image Credit (Trusted Reviews)Īnd yes, you can easily deactivate Kindle Kids in the Settings menu and simply use the Amazon Kindle Kids (2022) as a plain old Kindle. There’s also a built-in vocabulary builder, which makes a note of any words that the child has looked up for later reference. There’s a gamified element to the Kindle Kids UI too, which awards achievements for reaching your daily reading quota, finishing a book, and the like. You can also pick which of the books in your own personal library you want to share and make accessible to your kids. Through this UI you get a streamlined experience, with only kid-friendly books pushed to the fore. You get the same software experience on the Amazon Kindle Kids (2022) as you do on any other Kindle, but with the Amazon Fire for Kids feature set-up from the off. If it breaks, you can return it and Amazon will replace it for free. Like the previous model, any accidental damage inflicted upon the e-reader will be covered by the retailer. Thankfully, this is where Amazon’s two-year worry-free guarantee comes in. You’re best off investing extra in the Kindle Paperwhite Kids if that’s likely to be an issue. ![]() So if little Jenny’s drinks lid comes off in said school bag shake-up, their Kindle is unlikely to survive the encounter. One related design criticism we had for the Kindle (2022) perhaps applies doubly so with the Kindle Kids (2022) – it has no form of waterproofing whatsoever. ![]() Subtle but strong magnets should keep the lid closed even when shaken up in a school bag. It’s very effective at warding off knocks to the corners, while the thick padded display cover will keep the screen suitably protected when not in use. It’s a fairly cheap and plasticky folio that’s available in a couple of colourful designs. The key differentiating point between the Amazon Kindle Kids (2022) and the Kindle (2022), at least externally, is the protective case that the former comes in. But it’s not so bad that you’ll be fearing for your child’s eyesight when they’re reading in bed of an evening. The Kindle Paperwhite Kids is available for £139.99 if you want the absolute peak of screen clarity for your child. Going back to that screen for a second, the lighting isn’t the boldest or most even of any Kindle – a clear sign of budget-induced compromise. It took me a while to even notice the tiny power button on the bottom edge, right alongside the USB-C charging port. All interactions are through that display, which is recessed slightly in a way that further discourages nicks and scratches. The super-simple Kindle design makes perfect sense in the hands of a kid, with no page-turning buttons to get jammed up by slobber and cookie gunk. At 256g (including the cover), it weighs just a little more than a large smartphone, which feels like nothing at all spread over a larger surface area. Obviously it’s much wider at 108.6mm, with an aspect ratio that’s intended to mimic a page out of a paperback. At 157.8mm, it’s not much taller than an iPhone 14. It’s very compact for an e-reader, with a shorter height than many current phones. What was easily wieldable by a single adult hand in the Kindle (2022) remains easy to wield in two here. ![]() That makes even more sense packaged up in this Kids version, where the hands holding it will be on the petite side. This screen is still a fairly compact 6 inches in size, like its predecessor. This feature alone is a good reason to upgrade from the 2019 model and its (comparatively) fuzzy 167 PPI screen. The biggest and best feature of the Amazon Kindle Kids (2022) is its display, with a super-sharp 300 pixels-per-inch (PPI) resolution that really makes text pop. Rather than ask you to traipse through our 4.5-star review of that fine e-reader, however, let’s summarise how it looks and feels with the added perspective of someone with teeny-tiny hands and a total inability to sit still. As I mentioned at the outset, the Amazon Kindle Kids (2022) is an Amazon Kindle (2022). ![]() ![]() ![]() Today, at SES Chicago, Phil Mui announced additional features that build on these same themes to make your life as an analyst easier. By checking this box, you can make the annotation apply to all projects that you own.We all love the holiday season, and so now, here are a few reasons to love it even more! A few weeks ago, we announced a set of powerful, flexible, and intelligent features. By checking this box, you can make the annotation apply to all data views in the company.īy default, the annotation applies to the current project. The new calculated metric will not automatically display the annotation for orders the calculated metric must be also be added to the scope section for the annotation to be displayed.īy default, the annotation applies to the originating data view. You then use Orders in a calculated metric for the same date range. However, a new annotation should be created for any filter that you wish to annotate with the same information.Įxample: You apply an annotation to Orders on a specific day. The desired calculated metric must also be added to the scope section to display the annotation. Note: Any annotation applied to a component that is then used as part of a calculated metric or filter definition does NOT automatically inherit the annotation. Or your Visits metric isn’t reporting any data - follow the same process. Drag the eVar into the Any of these metrics are present dialog. Use cases: An eVar has stopped collecting data for a specific date range. With all of these filters: Drag and drop up to 10 dimensions or filters that will filter when the annotation shows.Any of these metrics are present: Drag and drop up to 10 metrics that will trigger the annotation to show.If you don’t specify a scope, the annotation will apply to all your data. Then drag and drop any dimensions or filters that act as as filters (i.e., that the annotation will be visible with). (Optional) Drag and drop the metrics that trigger the annotation. Color can be used to categorize annotations, such as public holidays, external events, tracking issues, etc. The annotation appears in the project with the selected color. Select the date or date range that needs to be present for the annotation to be visible.Īpply a color to the annotation. (Optional) Organize annotations by creating or applying a tag. (Optional) Provide a description for the annotation, e.g. These APIs use the same data and methods that Adobe uses inside the product UI. The Customer Journey Analytics Annotations APIs allow you to create, update, or retrieve annotations programmatically through Adobe Developer. Use the Customer Journey Analytics Annotations API Note that by using the hotkey to create an annotation, you create a single-day annotation for the current date, without any pre-selected scope (metrics or dimensions). Use this hotkey to open the Annotation builder: (PC) ctrl shift + o, (Mac) shift + command + o In Workspace, go to Components > Create annotation. Also notice that the date/s and any metric, etc., have already been populated. But you can make them available to all projects. Note that, by default, annotations created this way are visible only in the project where they were created. Click Create New Annotation and the Annotation builder opens. To create annotations, you have several ways to get started:.However, Admins can give the Annotation Creation permission (Analytics Tools) to users via the Adobe Admin Console. Users have rights to view annotations like they do with other other Analytics components (such as filters, calculated metrics, etc.). By default, only Admins can create annotations. ![]() ![]() Users can generate PDFs, print-ready documents, or even export in eBook formats, making it a versatile tool for various output requirements. Users can create shapes, lines, and curves directly within the application, eliminating the need for third-party graphic software.įor projects that require a multi-lingual approach, iCalamus supports Unicode, ensuring that you can work with diverse languages and character sets seamlessly.Ĭollaboration is made easy with iCalamus thanks to its export capabilities. ICalamus also includes impressive drawing and illustration tools. It’s a time-saving feature for projects with repetitive elements. This means you can create consistent layouts across multiple pages or sections of your document. One notable aspect of iCalamus is its support for master pages. This feature is particularly valuable when working on complex layouts that demand precision. Users can adjust fonts, colors, and styles to achieve the desired look and feel.įurthermore, iCalamus offers a precise positioning system, allowing you to align and distribute objects with pixel-perfect accuracy. From text formatting and typography to image manipulation and scaling, it covers all aspects of design. ICalamus provides a wide range of design tools to enhance your creative projects. ![]() Whether you’re incorporating text from a Word document or importing images from Photoshop, iCalamus ensures seamless integration. It supports various file formats, making it easy to import and export content. Whether you’re working on a book, magazine, poster, or flyer, iCalamus offers the necessary tools to achieve your vision.Ī key strength of iCalamus is its flexibility. Users can effortlessly arrange text, images, graphics, and other elements to create visually appealing documents. VideoByte DVD Creator 5Īt its core, iCalamus is a comprehensive layout and design tool. The intuitive layout and easy-to-navigate menus ensure that users can quickly get started on their projects without a steep learning curve. One of the standout features of iCalamus is its user-friendly interface, which makes it accessible to both beginners and experienced designers. This Mac-exclusive software is tailored to meet the specific needs of Mac users, providing a seamless and intuitive workflow. ICalamus offers a sophisticated desktop publishing experience on macOS, allowing users to unleash their creativity and produce professional-quality publications. Here’s a comprehensive overview of iCalamus, with all keywords bolded: With its powerful set of tools and user-friendly interface, iCalamus empowers individuals and businesses to create visually stunning documents, brochures, newsletters, and more with ease. ICalamus is a versatile and feature-rich desktop publishing software designed exclusively for Mac users. ![]() iCalamus is a powerful and versatile software utility for creating everything from simple posters to complex magazines, scientific works, and book publishing. Download iCalamus 2 full version program free setup. ![]() 1/6/2024 0 Comments Marvel gi joe roadblock![]() ![]() Noah is a new character written for Rise of the Beasts, but the battle suit he wears for the film’s climax appeared in U.K.-exclusive pages of the 1984–1991 Marvel Comics series The Transformers, where it was referred to as a G.I. Joe, in which the Joes travel to the Transformers’ home world of Cybertron and team up with the Autobots against Cobra and the Decepticons. Joe and the Transformers, in which the two teams joined forces, and as recently as 2017’s Transformers vs. The two properties have never crossed over onscreen until now, though they’ve done so in comic books as early as 1986’s G.I. Joe dominated kids’ media in the ’80s, first as a line of Hasbro action figures and then as popular (but separate) Saturday-morning cartoons. Then he enters a secret bunker in the warehouse and hands Noah his business card, which identifies said organization as “G.I. Turns out Burke has been keeping tabs on Unicron, and he tells Noah that the organization he works for would like to enlist his and the Autobots’ services for a global peacekeeping mission. There, he reveals that the organization he works for knows all about the Autobots and Noah’s role in saving the world. Noah’s world-saving efforts land him on the radar of Agent Burke (Michael Kelly), who invites him to what seems like a normal job interview for a security position at a warehouse. Noah also walks away with a sweet new battle suit made from parts of his Autobot pal Mirage (Pete Davidson), which he used to join Optimus Prime (Peter Cullen) and Optimus Primal (Ron Perlman) in the final battle against Unicron and his servant, Scourge (Peter Dinklage), who meets his end with a face full of molten lava in Peru. The space- and time-portal-opening Transwarp Key has been destroyed, and our heroes - the Autobots (the alien robots who turn into cars), the Maximals (the alien robots who turn into animals), and human protagonists Noah (Anthony Ramos) and Elena (Dominique Fishback) - stand united in their efforts to protect earth. ![]() We leave Rise of the Beasts with the threat of the Terrorcons, a group of evil Transformers, and their leader, the world-devouring Unicron, defeated for now. Welcome to the Hasbro Cinematic Universe. Joe is back again, and it is handing out business cards. With its final scene, Transformers: Rise of the Beasts officially introduces the special-forces organization G.I. Like an ’80s kid mashing action figures together, the Transformers franchise is in its crossover era. We are recirculating it now timed to Transformers: Rise of the Beasts’ digital release. This article was originally published in June. ![]() 1/6/2024 0 Comments Yate wedding dresses![]() ![]() Alice and Yates are two of the kindest people and I am honored they asked me to photograph their beautiful wedding!Įven though Alice is not a coffee drinker (I know… I can’t fathom it either), she and I had a great rapport and that’s exactly what you want on your wedding day. ![]() Through the last few months, we discussed all the details of her wedding day from when should she start getting ready to reception timeline and how they should exit. Our high quality pieces are known world over for their exquisite designs which complement the female form and look absolutely lovely no matter the setting.In February, I finally got to meet these two face-to-face when we did their engagement session the day before Alice’s best friend, Anna, got married (which I also photographed – check it out here). Have the dress of your dreams at a clearance price. Our affordable dresses also come in every style imaginable, from mermaid to sweetheart to the grand drama of a magnificently long train. With colors ranging from crisp white to crème to eggshell, there’s a white shade to complement every skin tone. ![]() TheDressWarehouse has a vast discounted wedding dress inventory, full of wedding gowns in all styles and shapes. There’s one event in particular which may be bigger than others – your wedding. At TheDressWarehouse, you can buy the dress of your dreams but at an affordable price. Our sale items are stunning, yet with clearance prices. For those with expensive tastes, but wishing to stay within budget, TheDressWarehouse is the perfect fit. Many events such as weddings, galas, evening events and proms can be quite expensive. Find Your Dream Wedding Gown at TheDressWarehouse ![]() Whether you’re getting married on the beach and looking for something simple and flowy or in a garden and looking for a true statement piece, our vast discount inventory is sure to have the perfect piece for you. In addition to our extensive color and shape options, we can find the perfect dress to fit your theme. With our wide range of designers, TheDressWarehouse is sure to have the perfect wedding dress for you. Featuring longer sleeves and floor-length hemlines, these dresses are opulent yet refined, with the perfect amount of intricate detail to draw the eye. We also carry more demure designs, such as those for Mother of the Bride or Groom. Jumpsuits and form-fit dresses also add a sense of drama, with the material hugging the skin and outlining the body’s shape. They are also excellent choices for those looking to de-emphasize their hips or add the illusion of curves.įor those looking for more flare, consider dresses with accents such as deep Vs, low backs, high slits, long trains and larger accessories such as bell sleeves or bows. We have many colors and styles for each dress shape, making it possible to find the perfect dress to accentuate each and every woman’s silhouette.Ī-line dresses are best suited for those looking to draw attention to the narrowest part of the body, nipping in at the waist. We carry a range of styles, so finding the right wedding dress to complement your unique body shape, skin tone and event is just a matter of looking through our extensive collection. Affordable Wedding Dresses for Every Body Thanks to our markdown prices, you will find that the designer wedding dress of your dreams will be more affordable than you think. From the classical A-line gown with a long train, fitted sheath or mermaid gowns, our collection of wedding gowns offers you a broad choice. Our wedding dresses cover the spectrum from contemporary to traditional, in a variety of silhouettes. Women come in all colors, shapes and sizes, and your love story is as unique as your sense of style. DressWarehouse is proud to rise to the occasion. You will want a dress that reflects all that, and which will allow your radiance and personality to shine. You know that your wedding gown captures the essence of the beauty and romance of this special day, and the cherished hopes and dreams you have for your future. All our wedding dresses are created by internationally renowned designers whose hallmark is exquisite craftsmanship, inspired design, and high quality. We understand that there’s a good reason why, for every bride, the choice of gown is near the top of her list of priorities. At DressWarehouse, we know how important it is for you to find the right wedding dress. ![]() 1/6/2024 0 Comments Edwin diaz injury![]() ![]() As long as he’s deemed fully healthy in every which way, why not let him come back to pitch? Even if it’s just for one inning, that’s the kind of momentum any rehabbing player wants heading into the offseason. The man is competitive and set a goal of getting back before the regular season is done back in March. ![]() Regardless of how things go for the Mets, it’s important for Diaz to try and get back on the mound. The next couple of weeks will determine whether the front office will continue to buy or sell. However, they did show some life with six straight wins right before that. New York also went into the All-Star break with two straight losses to the San Diego Padres. When the injury first happened, everyone associated with the Mets said his season was done (despite there being a slight possibility of him returning). But, of course, the thought now is… well, what the heck is he working so hard to get back on the field for? The Mets stink! He’s a true athlete and really can recover quickly, so I hope to see him out there really soon. The New York Mets pitcher was playing for Puerto Rico in the World Baseball Classic on. The Mets closer could not put any pressure on his right leg and. He’s been going out and throwing 125 to 150 feet every day. Edwin Daz has taken to social media to thank fans for their messages following his season-ending injury. As Edwin Diaz jumped around celebrating Puerto Rico's monumental 5-2 victory over the tourney favorites, he crumbled to the turf. He asked him how Edwin is doing, to which the right-hander said this: He will have surgery and miss the entire 2023 season, according to GM Billy Eppler. Although he said Diazs injury 'broke my heart,' Lindor told reporters. The Mets closer hurt his knee during Puerto Ricos celebration after their win over the Dominican Republic in the WBC. Newsday’s David Lennon caught up with his brother, Reds closer Alexis Diaz, in Seattle at the All-Star Game. The injuries to Diaz and Houston Astros star Jose Altuve have reignited the debate over MLB players participating in the WBC. He’s continued to maintain hope that he can pitch again before the regular season is complete. The All-Star reliever has been on the comeback trail since getting surgery in March. But if we had to point our finger toward one event that could’ve possibly changed everything, it’s losing Diaz. But before Opening Day even started, New York lost closer Edwin Diaz to a freak injury during the World Baseball Classic.Ī lot of things have gone wrong for the Mets this year. The Mets entered 2023 with the highest of hopes (and expectations) after a 101-win season. ![]() ![]()
1/6/2024 0 Comments Fairytale fights gameranni![]() ![]() With a 10-level jump from the fight that immediately precedes this boss battle, Evice is one. Despite that it still managed to be huge among shonen fans. The Fairy Tail anime series, a show about a. Some believe that the anime is of a lower quality than the manga, others only prefer the anime for being simples and more focused on fun. Increasing the guild's rank will also allow players to learn more powerful kinds of magic. The final boss of Pokemon Colosseum is one of the hardest fights in the franchises history. New details for next years Fairy Tail RPG have been revealed, and include game length, number of playable characters and more. Fire Pokemon not only burn their opponents but they can also roast them with words, even if they are a Water-type. ![]() Since players will be taking control of the members of the Fairy Tail guild, they will be managing the guild itself, upgrading its facilities by completing requests given to them by the townspeople. This Feraligatr picked a fight with a Fire-type, and it is not going to end well. The Shadow Monster, Murkrow, is a dual Dark and Flying-type critter resistant to Dark, Ghost, Grass, Ground, and Psychic-type attacks, but it is weak against Electric, Fairy, Ice, and Rock-type moves. Unsurprisingly, DLC is being considered as well, so we can probably expect even more costumes and maybe new quests to be added post-launch. ![]() After Kirby and Ribbon defeat the creator of Dark Matter, Ribbon even gives Kirby a kiss on. And while it's not entirely clear whether the game will adapt any of the stories from the Fairy Tail series (or, if that is the case, which stories it will adapt), it is now confirmed that players will get to meet brand new characters, with their own storylines and quests. In Kirby 64, players get to control Ribbon during Kirbys fight against Zero Two, the games final boss. Along the way, they team up with Erza and Gray, with a few members jumping in and out of the. Firstly, we now know that the main game will last approximately 30 hours, which doesn't seem particularly long for a RPG but there will also be plenty of side content, such as character episodes and alternate costumes to acquire, which will no doubt lengthen the game. Fairy Tail follows the story of Lucy and Natsu as Natsu attempts to find his lost dragon father Igneel. ![]() |
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